Performance of Allergic Purpura

Performance】 【symptoms
The clinical manifestations of allergic purpura is: 1-3 weeks, often before the onset of upper respiratory tract infection. The first disease to the most common skin purpura, a few cases of anaphylactoid purpura purpura before the joint pain, abdominal pain, back pain, or hematuria, melena and so on. Usually based on parts of the lesions involving the clinical manifestations appear divided into the following types.
First, the most common type of purpura to dermal capillaries and small arteries is characterized by aseptic inflammation, blood vessel wall may have focal necrosis and platelet thrombosis. Most of the skin, recurrent petechiae, ecchymosis as the main performance, the most found in lower limbs and buttocks, symmetrical distribution, occur in batches, petechiae vary in size, was purple, can be integrated into tablets or slightly higher than the skin surface. Was bleeding and other measles-shaped papules or small, can be accompanied by mild itching. Integration of National Cheng Kung University Xuepao severe cases, the center was hemorrhagic necrosis. Petechia, ecchymosis gradually subsided in a few days can also be repeated, a few cases may be associated with eye face, lips, hands, feet and other limitations of angioedema.
Second, the abdominal (Henoeh purpura) mainly as abdominal pain, located around the navel or lower abdomen, often has colic or persistent intermittent dull pain can be accompanied by nausea, vomiting, diarrhea, blood in the stool. As serous bloody discharge into the intestinal wall, caused by submucosal edema, hemorrhage, caused by irregular bowel motility can cause intussusception. If the symptoms of this type before in skin purpura misdiagnosed as acute abdomen.
Third, the joint type (Schonlein purpura) in joint swelling, and pain, more common in the knee, ankle and other large joints, joint cavity can be fluid, but not purulent. Recurrent pain, were migratory, may be associated with redness, swelling and movement disorder, usually subside in a few months, after leaving abnormal fluid absorption. Before the event of the purpura misdiagnosed as rheumatoid arthritis.
IV --- also known as renal purpuric nephritis, more common in youth, often appears in purpura 1 Zhoufa Sheng, who occasionally until 7-8 weeks. Showed proteinuria, hematuria, urinary tube, sometimes accompanied by swelling, usually recover in a few weeks, there are recurrent, persistent for several months by. Even a small number of lesions involving the entire kidney and the development of chronic nephritis or nephrotic syndrome, uremia occurred individually.
V. rare type of mixed type and type of clinical manifestations of the above, if any exist two or more are called mixed. Which also have symptoms of abdominal and joint type are known as Henoch-Schonlein purpura. Others such as lesions involving the central nervous system, respiratory system and other symptoms may appear appropriate, a few may have optic atrophy, iris or conjunctival inflammation, retinal hemorrhage.

Diagnosis of allergic purpura is mainly based on skin purpura, capillary fragility test was positive in some patients. Bleeding time, clotting time, platelet count, clot retraction test and bone marrow examination were normal. If the merger increased the total number of infected white blood cells; parasite infection can be increased when eosinophils; involving the kidney may have hematuria, proteinuria or urinary tube; involved when intestinal fecal occult blood until the blood will be positive.

Henoch-Schonlein purpura in Chinese medicine as "spot", "rash", "Nvxue" category. More commonly due to yin, Wang Xing due to blood heat, but there are Deficiency and the like. The performance of those who have fever, the use of heat and detoxifying, cooling blood and yin, and other methods to stop bleeding Xiaoyu; performance by Xu Zheng, the use of qi and blood, spleen Ning heart, nourish liver and kidney and other laws, both wind-heat, humidity, etc. disease, heat and dampness should Zhuojia Shufeng the goods.

The Cause of Allergic Purpura

Allergic purpura (allergic purpura) is a common allergic hemorrhagic vascular diseases. Is because the body is allergic to certain allergens occurred, causing a wide range of small vessel vasculitis, making the small arteries and capillary permeability and fragility, with exudative hemorrhage, edema. The main clinical manifestations of allergic purpura purpura skin and mucous membrane bleeding may be associated with skin rash, joint pain, abdominal pain and kidney damage. Henoch-Schonlein purpura in children and adolescents is more common, more men than women, mostly in spring and autumn disease.

】 【Etiology
The direct cause of allergic purpura is often difficult to determine the relevant factors are:
First, bacterial infection (caused by β hemolytic streptococcus most common upper respiratory tract infection, in addition there are Staphylococcus aureus, streptococcus pneumoniae, Mycobacterium tuberculosis), viruses (rubella, chicken pox, measles, influenza), and intestinal parasites .
Second, food fish, shrimp, crab, eggs, milk and other food heterosexual protein.
Third, drug antibiotics (blue, chain, red, chloramphenicol), sulfonamides, isoniazid, anti-inflammatory drugs (salicylic acid, phenylbutazone, quinine, etc.).
Fourth, others such as cold, pollen, insect bites, vaccinations and so on. These factors antigen - antibody complex reaction, this complex deposition in the vessel wall or the glomerular basement membrane, and activate complement, release of allergens such as, damage capillaries, arterioles, capillaries, causing widespread inflammation, even necrotizing inflammation of small arteries, the blood vessel wall permeability and fragility increase, leading to subcutaneous tissue, mucous membranes and internal organs, hemorrhage, edema. Gastrointestinal tract and joints can have a similar change. Focal renal lesions are mostly light nephritis, can have severe local necrosis or total glomerular renal involvement. Some scholars believe that the disease is rapid onset allergic reaction, a large number of IgE. Adsorbed on the mast cells, release of biologically active substances which have caused the damage.