Hypertension with hyperlipidemia how to choose antihypertens

Hypertension with hyperlipidemia, the choice of antihypertensive agents principle is both good antihypertensive effects, does not affect lipid metabolism. In recent years, the study found that diuretics and beta-blockers have antihypertensive effect and can reduce the incidence of stroke and death. but does not reduce the incidence of coronary heart disease and death. It was pointed out that this may be related to diuretics and beta-blockers on blood glucose and lipids affect the outcome. It has been proved that they can make blood total cholesterol, low-density lipoprotein and triglyceride levels rise, so that lower high-density lipoprotein, which is the result of atherosclerosis risk factors. Therefore, over a period of time, home and abroad are on diuretics and beta-blockers as first-line antihypertensive drug without reservations. But there are also reports, such as low-dose diuretics hydrochlorothiazide, taking 50 mg daily following, not only significant antihypertensive effect, but on blood lipids, blood glucose and has no effect. Even a slight impact, the withdrawal in the near future will be able to resume a normal, it is felt that the diuretics and beta-blockers for blood glucose, Lipid the adverse effects may be related to the excessive use. In vasodilator, α1 receptor antagonist prazosin physically lowering cholesterol, triglyceride, elevated serum high-density lipoprotein good role, in patients with hypertension and hyperlipidemia ideal drug. The drawback is that there is a small number of "first-dose effect", that is, when the drug first appeared orthostatic hypotension, syncope, palpitation, and so on. Small dose treatment, the incremental dose, it would avoid such side effects occurred. Calcium antagonists such as nifedipine, nimodipine, nitrendipine, verapamil, diltiazem in, through a complex mechanism, inhibition of extracellular calcium into the cell, so that the contraction of the cells weakened, such as a decrease in cardiac contractility, vascular dilation, resulting in decreased blood pressure. But also middle inhibit vascular smooth muscle cell proliferation and calcium deposition in the vascular wall reduction, and red blood cells, WBC and platelet adhesion in the wall, and then play against atherosclerosis role. In addition, such drugs on blood lipids and electrolyte affect small changes in blood flow to a good effect, it also applies to the merger of hypertension in patients with hyperlipidemia treatment. Angiotensin-converting enzyme inhibitors such as captopril, enalapril, long-term use of lipids no adverse impact Antihypertensive but obviously, a significant role in the protection of the heart.