What is microangiopathic hemolytic anemia?

Microangiopathic hemolytic anemia due to occurrence of endometrial microvascular thrombosis, stenosis or necrosis. When the red blood cells flow out of date conflicts caused RBC broken and the mechanical hemolytic anemia. In vitro and animal experiments showed that RBC in this abnormal microvessels were entangled in cellulose filaments, the blood pressure of the push, RBC was fragmented filaments occurred intravascular hemolysis; RBC or temporarily closed their own gap, blood circulation in emerging triangle, helmet-shaped and other forms of cell disruption and spherical cells, After the spleen or other monocyte macrophages  system was damaged. Many diseases can be associated with microangiopathic hemolytic anemia, these diseases can be divided into two major categories : ① to vascular disease or abnormality. Small arteries (particularly renal artery) disease often leads to fibrin deposition diseases such as hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, malignant hypertension, acute glomerulonephritis, renal cortical necrosis, Kidney transplantation exclusion, such as pregnancy-induced hypertension syndrome can occur hemolytic anemia. Other parts of the small arteries or necrosis, such as nodules polyarteritis nodosa, necrotizing granulomas, allergic vasculitis and huge cavernous hemangioma, also may be associated with vascular lesions thrombosis, RBC caused mechanical damage and hemolysis. ② vascular disease, and to disseminated intravascular coagulation-based. Placenta prematurely removed, the shock associated with sepsis and promote coagulation venom poisoning caused by hemolysis, are disseminated intravascular coagulation-based. Extensive cancer metastasis, especially breast cancer and stomach cancer have aroused such anemia. This is because the cell mucin secretion with thrombosis, can cause intravascular coagulation. The main clinical manifestations of the primary disease, the various manifestations of hemolytic anemia increases the performance. If hemolytic sudden, rapid development indicates that a hemoglobin. See the enlargement of liver and spleen. RBC morphological changes, blood tablets of varying how many broken RBC, made an important basis for the diagnosis. Therefore blood film diagnosis is very important. Treatment should address the main primary disease. If the primary disease is curable, hemolysis also can be stopped. Hemolytic such as disseminated intravascular coagulation caused by heparin treatment may be effective. Anemia can be serious transfusion. Prognosis depends on the primary treatment for the disease effectively.