Vigilance primary vasculitis lead to kidney damage

A clinical performance: M PA and WG occurs in the elderly, men多见. Patients with early disease are more systemic symptoms like fever (low heat or high fever), weight loss, anemia, skin purpura, muscle pain, joint pain and peripheral neuritis, these symptoms of the disease is not specific, but suggested that the disease is Significance. Most likely to suffer kidney, patients showed nephritis syndrome (both hematuria, a «three cases have gross hematuria, glomerular source hematuria), is still a small number of patients with nephrotic syndrome. Renal damage was carried out, as well as acute renal failure. The extent of involvement of pulmonary easy Habitat Secondly, the patients cough, hemoptysis and shortness of breath, light, with only sputum Blood-streaked phlegm, weight, even hemoptysis choked to death. Chest X-ray inspection, M PA can lobular pneumonia-like shadow of a widespread or pulmonary hemorrhage shadow (the shadow-intensive small powder form, by the hilar to the expansion of a butterfly on both sides of lung field, the upper and lower lung field clear), while the main WG Limitations or cavity with necrotizing pneumonia (one to several round or oval-shaped thin-walled empty). WG involved in addition to the lower respiratory tract, often arising from violations of the upper respiratory tract, such as sinusitis. In addition to kidney and lung, other organs such as the central nervous system (cerebral infarction and cerebral hemorrhage), heart (myocardial infarction), the digestive system (abdominal pain, bleeding, pancreatitis and cholecystitis) and the reproductive system (testicular inflammation) can be involved, And eyes (keratitis, scleritis, pigment uveitis and retinopathy), ears (nerve deafness) disease is not uncommon. 2 pathological changes: M PA and WG major violations of arteries, capillaries and veins of small, often for small vessels of multiple organ system involvement, and basic diseases for the vessel wall leukocyte infiltration and cellulose-like necrosis. WG peripheral vascular disease can also be seen in the characteristics of granuloma (by the large number of monocytes, multinucleated giant cells, epithelial cells and fibroblasts cells). Kidney involvement, the light microscope examination showed glomerular necrosis and cellulose-like (or) crescent formation, WG patients can be found in the renal interstitial granuloma. Kidney arteries can be a vasculitis performance, but also the normal (it is not because of the kidney arteries normal and that the disease). Immunofluorescence check glomeruli often no, or only trace of non-specific immune sediment (and thus the disease is also known as "micro autoimmune nephritis"). Electron microscope examination of a dense presence.