Aerobic gram-negative bacteria of major pathogenic bacteria are the most common are E. coli and Proteus. Proteus has a strong synthesis of urease's ability to break down urea urease, so that the alkaline urine, leading to precipitation of phosphate, to form magnesium ammonium phosphate and calcium phosphate stones. Klebsiella spp synthesis of urease weak, but other synthetic stones favor of the formation of the material.
Gram-positive cocci, especially coagulase positive staphylococcus (aureus on the surface, parasitic corruption aureus), Staphylococcus aureus and Streptococcus Group D (enterococci) has also given rise to the occasional Acute pyelonephritis. Staphylococcus can be invasive way to the blood of kidney and urine disease caused by bacteria kidney abscess. Pyelonephritis caused by anaerobic bacteria in some rare cases.