Chronic atrophic gastritis and gastric carcinoma?

In recent years, numerous studies show that atrophic gastritis and associated with the intestinal metaplasia, cell dysplasia and the incidence of gastric cancer there is a close relationship. Atrophic gastritis accompanied IM, it was both statistics and see who accounted for 66.5%, but growth and increased with age. IM is 71 glandular epithelium, is the normal gastric epithelial intestinal epithelium was replaced, metaplasia within the cytoplasm in normal gastric mucosa contains a lot of undue by intestinal enzymes within the cell, such as aminopeptidase. 5-nucleic acid and alkaline phosphatase activity, intestinal metaplasia in glandular epithelial cells and can absorb some of lipids, intestinal metaplasia gland to make the original changes in the secretory function of absorption. Due to the lack of chylothorax lipid absorption so not as small as the immediate importation of intestinal blood circulation, but stranded in the gut gland epithelial metaplasia, gastric district is not an effective antidote, thereby creating carcinogenic substances induced gastric cancer. The atrophic gastritis with intestinal metaplasia close relationship with gastric cancer, reported more mainly that the following evidence : ① have stomach cancer compared with benign lesions of the stomach, intestinal metaplasia of its high incidence and widespread; ② intestinal metaplasia and carcinoma of the location is very similar to that of the gastric antrum and small bending and bending than gastric tumor. ③ high incidence of gastric cancer than the low-risk area of gastric cancer, intestinal metaplasia styles; ④ majority of gastric cancer with the Department of intestinal polyps make a mushroom cancer intestinal metaplasia in the neighborhood; ⑤ direct histological evidence of cancer may occur in the intestinal metaplasia site, It was also confirmed from intestinal metaplasia shift behavior cancer. In recent years, using electron microscopy and staining methods of intestinal metaplasia of the type of in-depth research, IM will be divided into complete and incomplete forms. Complete type of intestinal metaplasia, epithelial differentiation, and is a common mucosal lesions, widely found in various benign stomach trouble, considered to be the result of inflammation; not complete for colon metaplasia, epithelial differentiation poor, benign gastric diseases in the detection rate is low, while in lymphnodus mucosa adjacent to the high rate of detection. Note the colon and intestinal metaplasia of gastric cancer are closely related to the occurrence of precancerous lesions. Atrophic gastritis, metaplasia of epithelial cancer cells is the den, the more serious the chemical, the greater the opportunity carcinogenesis. In addition, atrophic gastritis associated with mucosal dysplasia (dysplasia), The gastric dysplasia refers to gastric epithelial cells and glands of a class deviation from the normal differentiation, or functional morphology was abnormal sexual performance of hyperplastic lesions. Generally believed that before the outbreak of malignant tumors, almost all first dysplasia. Hyperplasia more mild inflammation caused by, the natural downturn, moderate and severe dysplasia, carcinoma of the precancerous lesion. Atrophic gastritis pH and nitrite content. Low acid in the state, especially stomach bacteria nitrate reductase positive bacteria prompted a number of nitrate to nitrite reduction. food and nitrogen material integrated into carcinogenic substances  N-nitroso compounds, be considered atrophic gastritis cancer into an important factor. In addition, atrophic gastritis and gastric acid lack of chronic inflammation, often associated with stomach ulcers and polyps, and the ulcer and gastric adenomatous polyps also precancerous gastric lesions.