How diagnosis of chronic atrophic gastritis?

Chronic atrophic gastritis in non-specific clinical performance The diagnosis of chronic atrophic gastritis needs associated with clinical examinations, especially gastric endoscopy and biopsy. Below systematically introduces chronic atrophic gastritis diagnosis based on : (1) clinical manifestation : mainly anorexia, nausea, beching was, upper abdominal pain or satiety, a small number of patients may have upper gastrointestinal bleeding, weight loss, anemia, a crisp, Geographic Tongue nipple or shrinkage. (2) laboratory ① gastric analysis : A CAG patients more acid-free or low-acid, CAG patients with type B can be normal or low acid. ② pepsinogen Determination : the main reason pepsin secretion, chronic atrophic gastritis, Blood and urine of pepsinogen content decreased. Determination of serum gastrin ③ : antral mucosa cells in the G gastrin secretion. A CAG patients, serum gastrin often significantly higher; CAG patients with B-type gastric mucosa atrophy, G cells directly affect functional gastrin secretion and serum gastrin lower. ④ immunological tests : parietal cell antibodies (PCA), which factor antibody (IFA), gastrin antibody-secreting cells (GCA) measured as chronic atrophic gastritis and its sub-type of diagnosis. (3) X-ray inspection : X-ray stomach barium meal examination majority of patients with atrophic gastritis found no abnormality. Double-contrast barium enema can show that the gastric mucosa folds flat, to small, large gastric mucosa curvy serrated folds to small or disappeared, fundus smooth, some gastric antral gastritis can be serrated or mucosa showed crude manifestations of chaos. (4) endoscopy and biopsy : endoscopy and biopsy is the most reliable method of diagnosis. Gastroscopic diagnosis should include lesions, atrophy, intestinal metaplasia and dysplasia level. Direct observation of observation atrophic gastritis mucosa formed a pale or gray, plica to small or flat. Mucosa may be in a red and white seriously, in a casual white plaque. Mucosal vascular exposed to atrophic gastritis features, we can see the red mesh small arteries or capillaries, serious atrophic gastritis, there are some epithelial cells forming small particles or larger nodules. Also mucosal erosion, bleeding. Gastric biopsy mainly varying degrees glands shrink and disappear, replaced by pyloric glandular metaplasia or IM, AD interstitial inflammatory infiltration significantly.