Gastrinoma the clinical manifestation is what?

Peptic ulcer disease is the most common symptoms, the incidence of about 90%, with 75% more patients complained of abdominal pain. Pain is difficult to its characteristics and the general canker distinction, but right antiulcer drug reaction is characterized by poor, Some patients pain heavy, continued to ease, and which was conducted during the course; its hemorrhage, complications such as perforation than the general canker styles; When the usually canker OK subtotal gastrectomy, often in the early postoperative period is soon anastomotic ulcer perforation and bleeding, this is the one of the clinical features of disease. The majority of ulcer disease is a single, middle size, can have great hair or ulcers, according to reports, The ulcer disease about 75% distribution in the duodenal bulb and 14% located in the descending portion of the duodenum, 11% distribution in the jejunum. This feature and the general canker ulcer distribution significant difference. In addition, the gastrointestinal mucosa can see a clear congestion, edema and erosion, and hypertrophic gastric reflux symptoms, even esophageal ulcer, stricture and Barrett's esophagus, which is the general characteristics of peptic ulcer disease are rare. The second of the disease common symptoms were diarrhea, incidence of approximately 1 / 3, The main reason for this is gastrinoma caused by high acid secretion. Gastric acid into the large intestine, small intestine over China and the ability of small intestinal mucosa caused direct injury, also enable pancreatic lipase with irreversible inactivation, and to stimulate a large number of secretin release, pancreatic secretion. In addition, gastrin itself promotes water and electrolyte secretion and inhibit their absorption. The above factors, resulting in diarrhea. Most patients often accompanied by diarrhea, abdominal pain, a small number of patients with diarrhea can only see and use it as a first symptom, without peptic ulcer, large can was water, often intermittent, and with peptic ulcer symptoms change, which can cause severe dehydration, acid-base balance and electrolyte imbalance, with some patients may see fat or poor absorption of vitamin B12 deficiency. For familial gastrinoma patients, most have a family history of endocrine neoplasia or family history of ulcer disease, its pancreatic lesions in parathyroid adenomas and hyperplastic with hyperthyroidism most common, we can see bone pain, pathologic fractures performance. Most of the patients have pituitary tumors, but only 30% have corresponding symptoms. It should be noted that gastrinoma the clinical symptoms in familial and sporadic gastrinoma patients without discrimination. 