Gastrinoma how treatment and prognosis?

Of the disease is fundamental for the resection of gastrin tumor. Right not found tumors and tumor resection were not fully available drug treatment. (1) surgery for tumor resection ① : Gastrinoma as completely resected, is gastric acid secretion and serum gastrin will quickly return to normal. In pancreatic, parenteral, or in the duodenum gastrinoma, often as a single, complete surgical excision is more likely. Located in the pancreatic tumor can be completely removed, and were cured were less than 10%; If surgery can not find any pre-positioning of tumor should be careful exploration of rare and unusual parts of the tumor might exist. ② associated with other endocrine tumors, such as parathyroid tumor patients many advocated the removal of gastrin tumor prior to parathyroid surgery, diarrhea, peptic ulcer symptoms usually after mitigation, acid and serum gastrin levels also fell. ③ OK highly selective gastric vagotomy operation can significantly reduce gastric acid secretion,  increase histamine H 2 receptor antagonist role of the acid and reduce their drug dose. (2) drug treatment ① acid drugs : When the tumor can not be removed, the acid drug therapy is a long-term, uninterrupted, Otherwise prone to peptic ulcer complications. Commonly used drug for acid  histamine H 2 receptor antagonist, medicine than ordinary patients with peptic ulcer larger. Cimetidine 0.6 grams / time, 6 times / day, oral (with a few up to 5 ~ 10 g / day); Ranitidine 0.3 g / time, 3 times / day, oral. If he can take can be synergistic anti-cholinergic drugs, such as the stomach and Changning isopropylamine, reduce  histamine H 2 receptor blockers usage; Losec (omeprazole) is a cell wall acid pump inhibitor of the enzyme, various inhibited stimulation of gastric acid secretion, we have strong acid, for the treatment of this disease more effective drugs, a daily medication can effectively inhibit gastric acid secretion. Acid drug dosage should vary from person to person, generally BAO (basic gastric acid secretion) in 10 mEq / h can be the following. ② chemical drugs : not applicable to the tumor resection and metastatic, commonly used streptozotocin. If necessary, combined five  fluorouracil, to enhance efficacy. At present, many advocates from the celiac artery catheter streptozotocin interventional treatment, which will enhance efficacy and reduce adverse reactions. Once the disease gastrin tumor resection, symptoms will be controlled, the disease will be cured. Vicious gastrinoma, a vicious low, growth has been relatively slow, or even larger tumor with metastasis. 30% ~ 40% in patients with normal life despite 5 ~ 10 range. Death 80% died of complications of peptic ulcer and severe diarrhea caused by the water and electrolyte disturbance, especially severe hypokalemia, only a small number of patients died of cancer itself.