What is hemolytic uremic syndrome?

Hemolytic uremic syndrome is microangiopathic hemolytic anemia in a type. It is characterized by acute intravascular hemolysis, thrombocytopenia and renal failure coexist, and the prognosis is poor. Most patients for a two-age infants, 6 - 7-year-old children were more rare. Gasser 1955, and other reports and the first named the disease. Adults are aware of the special post-partum women have similar diseases. In children can sometimes occurred in 1915-1916, it is suspected that the virus may be related to some sort. Some patients before the onset against diphtheria, pertussis, polio, measles or smallpox vaccination. The pathogenesis of the disease is unclear. Some people think it may trigger kidney infection within the microvascular focal intravascular coagulation caused. Onset of symptoms is not heavy, more sudden diarrhea, vomiting, fever, sometimes for upper respiratory tract infection symptoms. 5 ~ 14 days there, looking pale and short, mild jaundice, urine reduce urine dark red or BB. Skin and mucous membrane bleeding may occur. Liver and spleen can be mild swelling. About half of patients with hypertension. Soon uremia and heart failure signs and symptoms, such as coma, convulsion, temporary paralysis and other symptoms of the nervous system. Anemia often more serious. Laboratory examination revealed WBC reduced or increased. Can be very low platelet count. Blood film showed a broken red blood cells and small spherical cells. Reticulocyte increased. A plasma free hemoglobin and serum bilirubin increased. Can be disseminated intravascular coagulation laboratories found, but some patients with normal coagulation factor, or increase, blood urea nitrogen, creatinine, Potassium often significantly higher. Urine contains a lot of protein, erythrocyte, leukocyte, tube and contains hemoglobin, hemosiderin-bile and urine. For the treatment of the disease in a timely manner using peritoneal dialysis, contribute to the improvement of conditions. Right a serious condition, with plasma exchange or exchange transfusion of whole blood often results very quickly. Severe anemia, can be concentrated erythrocyte transfusion. Best not to platelet transfusion to prevent the formation of micro-microvascular thrombosis. In Disseminated intravascular coagulation, many patients with heparin treatment, a significant improvement; However, there are winners probably too small dose used. Serious prognosis of the disease, the death rate is high, the majority of patients died of acute renal failure.