What is Rh hemolytic disease of newborns?

Because pregnant women and fetal Rh blood group incompatibility caused by the HDN, known as the "Rh hemolytic disease of newborns." On the Rh blood group system, a total of three pairs of six basic antigen, known as C, D, E, c, d, e, the corresponding antibody is called Anti-C-D-E, anti-c, d - (theoretically exists, has yet to be confirmed), e-antibodies. Each antigen controlled by a gene. Rh control of every gene on a chromosome three loci, respectively, by a gene of an occupation. In a three pairs of chromosomes with the allele may have eight different combinations. A fetal gene from the eight groups, which any group composed of two (CDE / cde, CDe / CcDE) One group from the sperm cells, another group from the egg cell. Six antigens to antigen D antigen, the strongest that D "E" C "c" e "d. By the anti-D antibodies caused by Rh hemolytic disease of the most serious, have the highest incidence rates. Therefore, the clinical usually containing the D antigen known as Rh-positive red blood cells, were not known as the D antigen Rh negative. If the woman for the Rh-negative (dd), the man of the Rh-positive homozygote (DD), They are the children born to Rh-positive heterozygotes (Dc); If the man for the Rh positive heterozygotes (Dc). then half of the children of Rh (D) - positive heterozygote, half of Rh (D) - negative. So, the father of Rh (D) homozygous, in the fetal Rh hemolytic disease of older father of Rh (D) heterozygotes were higher. Only Rh (D) - positive mother to fetus can D antigen sensitized Only Rh (D) - positive fetal erythrocytes liable to undermine anti-D antibodies derived from Rh (D) hemolytic disease. Although most of Rh hemolytic disease caused by the RhD antigen, but other Rh antigens such as E, C, such as e antigen can have Rh hemolytic disease of newborns. As other Rh antigens weaker antigen antibody role is relatively small and thus less symptoms. Du antigen is a special type of D antigen, and anti-D antibody response weak. In some ethnic groups in China have found this antigen. Du is the antigen that it is often mistaken for Rh negative, but if Du defeated RBC - Rh negative, may still have anti-D antibodies. Therefore, we must pay attention to the situation of Rh hemolytic disease. All nationalities in China were Rh negative is more rare. According to reports, Uygur, Kazakh, Uzbek, Tatar and Kirgiz were Rh negative 2% ~ 5% 11 other nationalities (including Han) not to 1%. Therefore, Rh hemolytic disease of the incidence rate was very low. In some because of Rh blood group incompatibility and the HDN cases, about 70% of cases caused by the antibody, Other anti-E, cE, CD and C, and so on.