Enter>>> feature of Behcet's disease
Behcet's disease is a small vessel vasculitis of unknown cause for the pathological basis of chronic, progressive relapsing, multisystem disease damage. To the mouth, genital ulcers, ophthalmia, skin lesions for clinical characteristics. The disease is autoimmune disease. Behcet's syndrome in traditional Chinese medicine for the disease first Fox set out in confusion, "Golden Lily Ann Fox slightly puzzled yin and yang, Treatment of toxic abnormal pulse." Chinese believe that the disease is "cold sores", "Yin ulcer", the card is, the cold, empty. The main pathological basis for the hyperactivity. Syndromes that the disease mainly in the liver heat, spleen and kidney is less wet and, therefore, TCM Differential Treatment of this disease is also carried out for the above three.
[Pathology and pathogenesis]
Etiology of this disease is not known, according to research, with several factors.
1 infection: It is reported that the disease and the acute and chronic viral infections, bacterial infections such as Streptococcus, Mycobacterium tuberculosis infection, caused by autoimmune disorders. For example: According to China to reports, the patients, one third in the past suffered from tuberculosis or are suffering from TB, some TB patients after treatment, not only to cure tuberculosis, and Behcet's disease symptoms have improved. It was also found that herpes simplex virus and the disease related with hemolytic streptococcus. That bacterial infection and the disease related.
2, genetic factors: a regional incidence of the disease tendencies, such as more common in Mediterranean countries. Characteristics of human genetic material that HLA study found that patients with Behcet the HLA-B5 positive rate of up to 60%, HLA-B51 positive rate is also high. Therefore, it was suggested that representatives of these two HLA types may be part of the genetic characteristics of Behcet's disease in the internal or the environment. Because not all patients with Behcet were HLA-B5 or HLA-B51 positive, Behcet autosomal recessive inheritance may be relevant.
3, trace elements: trace elements in patients with higher content of lesions, such as organic chlorine, organic phosphorus and copper ions. It was also found that certain trace elements zinc, selenium deficiency, may be related to the disease.
4, immune abnormalities: presence of serum antibodies against oral mucosa, antibodies against the arterial wall and other autoantibodies, immune complexes in serum positive rate of 60%, and with disease activity, patients with elevated immunoglobulin, lymphocyte imbalance, around blood vessels, cerebrospinal fluid, blood vessel walls and other lesions can be seen at the lymphocyte immune globulin, complement and other substances in the immune response, indicating that closely related to the disease and immune disorders.
[Clinical manifestations]
1, skin lesions: erythema nodules, common in the lower extremities, occur in the extensor side of the front leg, and sometimes also occur on the flexor side of the back and thighs, upper limbs and buttocks. Erythema diameter of 1-5cm, bright red, round or oval-shaped nodules, sometimes fused into large number of tumor nodules. After about 2-3 weeks, nodules from the red into a dark, gradually disappeared, no ulceration, nodular area often edema. Pseudo folliculitis can also occur, acne-like folliculitis, superficial thrombotic phlebitis performance. There is a class of rash with or without pus pus head head folliculitis, common in the face, neck.
2, recurrent oral ulcers: Oral ulcer disease accounted for 98% of patients, is the first symptom of Behcet's, but also have symptoms of attacks in more than three times a year during attacks in the buccal mucosa, tongue edge of the lips, soft palate, etc. there single or multiple a summary of the big red rice to soybeans, there is pain, followed by the formation of ulcers, ulcer diameter of about 2-3cm. Some like herpes onset, about 7-14 days after the self-limiting, leaving scars, ulcers after another, repeatedly. Factor of a few weeks in patients unhealed, left behind after a scar.
3, recurrent genital ulcers: ulcers common in female patients the size of the labia, followed by the vagina, the male scrotum, penis. Can also appear in the perineum and anus, the symptoms and oral ulcers similar traits, accounting for 80% of Behcet's.
4, ophthalmia: more men than women, the most common eye disease is also known as uveitis, uveitis, but also caused by vasculitis of the retina. The recurrent lesions. Can lead to serious visual impairment, severe can cause blindness.
5, system damage symptoms:
(1) the digestive tract: the digestive tract involvement can occur in multiple vascular ulcers, abdominal pain and other symptoms, severe cases, intestinal bleeding, intestinal paralysis, perforation and fistula formation. (2) the nervous system: a small number of patients have central nervous system involvement, meningitis, encephalitis, paralysis, increased intracranial pressure, spinal cord injury and peripheral neuropathy. Patients may present consciousness, paralysis, action instability, feeling disorders. (3) vessels: large, medium and small artery, vein inflammation causes tissue ischemia, venous obstruction and other symptoms. Artery when the blood vessels involved a large vein stenosis, occlusion, aneurysm formation or thrombosis. Pulmonary vascular involvement, there hemoptysis, shortness of breath, pulmonary hypertension, pulmonary embolism and other symptoms. (4) Joint: Common joint pain, swelling and a small number of the relevant section to knee involvement more common. In addition, some patients have a new disease activity or organ damage, accompanied by fever, fatigue, myalgia and other symptoms.
