This disease is an acute onset, with nerve root, peripheral nerve damage mainly associated with cerebrospinal fluid protein - a syndrome characterized by cell separation. Also known as Guillain-Barre syndrome. Both men and women of any age and disease, but young men is more common.
Etiology and pathogenesis is not fully understood, generally considered to have non-specific infection before the onset of vaccination history and history of allergic reactions caused by delayed immune diseases. Between the onset of infection to a latent period. Role in the immune response of peripheral nerve Schwann cells and myelin, resulting in limitations of segmental demyelination change around the vessels and nerves associated with endometrial lymphocytes, monocytes and macrophages infiltration. Axonal degeneration in severe cases can be seen, fragmentation. Myelin can regenerate in the same nerve fibers can be seen both demyelination and regeneration. Sometimes see the meningeal inflammatory reaction, spotting the spinal cord, anterior horn cells and motor nucleus of cranial nerve degeneration. Denervation muscle atrophy was.
The onset of clinical symptoms 1-4 weeks before there is a history of upper respiratory or gastrointestinal infection, or vaccination history. Four Seasons may be the disease, for many summer and autumn.
The clinical features of infectious diseases in 1 to 3 weeks after the sudden sharp pain to the nerve root (in the neck, shoulders, waist and lower extremities as much), and acute flaccid paralysis sexual symmetry of limbs, subjective sensory disturbances, or diminished tendon reflexes the main symptoms disappear. The specific performance:
(1) movement disorders: muscle paralysis of limbs and trunk are the main symptoms of the disease. Usually start from the lower extremities, and gradually spread to the trunk muscles, both upper limbs and cranial nerves, from side to side. Usually 1 to 2 weeks to peak in disease progression. Weight than the remote generally proximal paralysis, hypotonia. Such as breathing, swallowing and pronunciation involvement, spontaneous breathing can cause paralysis, difficulty swallowing and sound life-threatening.
(2) sensory dysfunction: General lighter, more from the extremities of numbness, tingling started. Can also be a sock-like feel diminished, disappeared, or allergies, as well as spontaneous pain, tenderness in the gastrocnemius muscle and the anterior horn obvious. Occasionally visible, or tracts of segmental sensory disturbance.
(3) launch obstacles: symmetry of limb tendon reflexes are mostly reduced or lost, abdominal, cremasteric reflex were normal. Small number of patients can be affected by the emergence of pathological vertebral beam reflector sign.
(4) autonomic dysfunction: the initial or recovery often sweating, sweat smell thick, may be the result of sympathetic irritation. Small number of patients may have short-term urinary retention initially may be due to the urinary bladder of a temporary imbalance in autonomic function or control of external sphincter damage caused by spinal nerve; stool Permanent Secretary of Results; unstable blood pressure can occur in some patients, tachycardia, and ECG disorders.
(5) cranial nerve symptoms: half of the patients had cranial nerve damage to tongue, pharyngeal, vagus nerve and one side or both sides of the peripheral facial nerve paralysis more common. Followed by eye, tackle, abducens nerve. Occasionally papilledema, optic nerve itself may be changed or cerebral edema caused by inflammation, it may be significantly higher CSF protein, blocking the arachnoid villi, impact on cerebrospinal fluid absorption. Diagnosis of infectious diseases, according to the disease suddenly appeared after the symmetry of the limbs distal sensory, motor and nutritional disorders and tendon reflexes can be confirmed.
