Allergic purpura (allergic purpura) is a common allergic hemorrhagic vascular diseases. Is because the body is allergic to certain allergens occurred, causing a wide range of small vessel vasculitis, making the small arteries and capillary permeability and fragility, with exudative hemorrhage, edema. The main clinical manifestations of allergic purpura purpura skin and mucous membrane bleeding may be associated with skin rash, joint pain, abdominal pain and kidney damage. Henoch-Schonlein purpura in children and adolescents is more common, more men than women, mostly in spring and autumn disease.
】 【Etiology
The direct cause of allergic purpura is often difficult to determine the relevant factors are:
First, bacterial infection (caused by β hemolytic streptococcus most common upper respiratory tract infection, in addition there are Staphylococcus aureus, streptococcus pneumoniae, Mycobacterium tuberculosis), viruses (rubella, chicken pox, measles, influenza), and intestinal parasites .
Second, food fish, shrimp, crab, eggs, milk and other food heterosexual protein.
Third, drug antibiotics (blue, chain, red, chloramphenicol), sulfonamides, isoniazid, anti-inflammatory drugs (salicylic acid, phenylbutazone, quinine, etc.).
Fourth, others such as cold, pollen, insect bites, vaccinations and so on. These factors antigen - antibody complex reaction, this complex deposition in the vessel wall or the glomerular basement membrane, and activate complement, release of allergens such as, damage capillaries, arterioles, capillaries, causing widespread inflammation, even necrotizing inflammation of small arteries, the blood vessel wall permeability and fragility increase, leading to subcutaneous tissue, mucous membranes and internal organs, hemorrhage, edema. Gastrointestinal tract and joints can have a similar change. Focal renal lesions are mostly light nephritis, can have severe local necrosis or total glomerular renal involvement. Some scholars believe that the disease is rapid onset allergic reaction, a large number of IgE. Adsorbed on the mast cells, release of biologically active substances which have caused the damage.
