Kaposis sarcoma

KS is an overview of the AIDS Malignancy representatives disease, the clinical features KS : idiopathic skin, multiple, pigmented sarcoma. That the African continent is an equatorial regions multiple places in the local geographic conditions, the principal violations of middle-aged and elderly men, Most occur in the limbs of the nodules of different sizes, after the disease claimed for Kaposis sarcoma. Cause pathogenesis of tumor nodules from the spindle cell and small vascular component. Such damage in the dermis of the middle and lower classes, and external to the formation of skin ulcers violations, violations within the bone. Nodules sometimes can be seen with bleeding and Hemosiderosis. Be around a small lymphatic expansion, infiltrating lymphocytes, plasma cell proliferative response and granulation, very shape of the rules. Sometimes it can be found in lymphatic sarcoma, Hemangiopericytoma Kaposis sarcoma and small within the multiple glomus tumors, and other changes. Clinical manifestations KS violations of the site is extensive, limbs, face and torso and other places, there can be skin, oral mucosa, eyelids, mucosa Department also occurred. In addition, lung, liver, spleen and other organs, especially when gastrointestinal bleeding risk prone. Clinical manifestations : ① nodular type : cherry red or purple, smooth surface, highlighting the skin surface, a state of mind, clearly, quality flaky. Oppression to bring the volume, eased 10 seconds restitution. This levy called Hayne's levy, the nodules can be distributed in the body throughout, but both lower limbs, feet and other places most common forearm. Typical lesions easy bleeding, but no pain, number of patients for the elderly. Survival of patients after 10 years. ② infiltration, the integration of lesions, ulcers or verrucous hyperplasia, often involving skin and bone tissue, This type usually occurs in the leg and foot, a nodular lesions exist. This type of quick progress, the survival period of not more than three years. ③ Pan hairstyle : in addition to extensive skin lesions visceral aggression and organizations, such as the gastrointestinal tract, liver, spleen, respiratory and other lymphoid tissue. Lymphoid tissue is violated, can be said to lymph nodes kind Kaposis sarcoma. Although the pan-onset cases only represent about 5%, but the condition develops quickly, and poor prognosis, and often life-threatening hemorrhage. Censorship (1) CD4 + T lymphocyte depletion : T lymphocyte function decline in peripheral blood lymphocytes was reduced significantly, CD4 "200 / μl, CD4/CD8" 1.0, delayed-type hypersensitivity skin test negative. mitogen-stimulated reaction low. (2) B lymphocyte dysfunction : polyclonal hypergammaglobulinemia, circulating immune complexes formed and autoantibody formation. (3) NK cell activity decreased. Treatment (1) treatment. ① Navelbine. ② VCR. ③ Etoposide is an effective treatment of AIDS drugs. ④ with bleomycin, adriamycin. (2) Radiation therapy can relieve symptoms and effective dose of 1800 -3000 rad. (3) partially frozen in liquid nitrogen. (4) BRM : interferon, Isoprinosine, thymosin alpha, interleukin - such.