Patients with hepatitis easily cause bleeding

Patients with hepatitis, especially hepatitis and severe chronic hepatitis late that often spontaneous bleeding gums, epistaxis difficult to stop, skin plaque deposition, injection site bleeding, blood in the stool, blood, Nixie, variceal bleeding after rupture, and that the two lower extremities and buttocks appear Purpura, such as bloody pleural effusion or ascites. Hepatitis bleeding reasons are complex, some mechanism is not yet clear, however, the following factors. (1) Hepatitis manufacturers to reduce the clotting factor. Exist in normal blood clotting substances and anti-coagulation factor, blood flow can not be solidified, and the site will enable timely hemorrhage bleeding. The liver is manufacturing Ⅰ, Ⅱ, Ⅴ, Ⅶ, Ⅸ, such as clotting factor Ⅹ organs. Hepatitis, suppression and destruction of these clotting factor on the quality and quantity so that the ability to reduce blood coagulation. (2) hepatitis increased consumption of coagulation factor. Liver cells bear the clotting material removal capacity, and this capacity hepatitis reduced inflammation but also promote coagulation live-like substances released, the clotting factor than usual consumption has increased significantly. (3) or hepatitis C virus antigen - direct-antibody complex vascular endothelial injury, activation of coagulation system, which can cause disseminated intravascular coagulation and blood circulation in the large-thrombus formation. Microthrombus the liver, kidney, brain and other organs of blood flow is obstructed, ischemia, necrosis and hemorrhage. (4) the role of hemostasis Fibrinolysis. Fibrin usually depends on the formation of liver removed. Hepatitis serious this capacity reduced to Fibrinolysis and bleeding. (5) the quality of platelet abnormalities. Platelets are blood hemostasis in the vanguard. Hepatitis viruses and immune complexes can inhibit the bone marrow to produce platelet reduction in the volume of damage. The whole process and hypersplenism intravascular coagulation and platelet destruction to excessive consumption also relevant. (6) Endotoxemia and closely related to bleeding. Hepatitis particularly severe hepatitis, from the gut, liver toxin can not be filtering, and entered detoxification flow will enable the release of thrombosis of blood caused indemnity temperature intravascular coagulation. (7) secondary infection. Severe hepatitis and chronic hepatitis decreased resistance to the body, various pathogens on either pneumonia, abdominal infections, skin abscesses, sepsis and deep bacteria infections. Pathogen infection and reproduction produced by the internal and external toxins, and immune substances combine to activate a large number of thrombosis blood coagulation system, leading to bleeding. In short, hepatitis bleeding, can be above a certain factors mainly, but also a variety of factors may be the result of the role.