Giant cell tumor of bone pathological changes

Giant cell tumor of bone will occur in the epiphysis of long-bone, particularly distal femur and proximal tibia is common, accounting for about half, followed by the distal radius bone, or distal ulna top of the humerus, and other sites. Outside the long bones of the spine while common.
Naked eye view, the tumor has often violated epiphyseal closure of the long bone end, the majority located in epiphysis, early often eccentric growth, increased cortical bone tumor involvement and the outward expansion. There are around in the tumor of low bone shell, a long bone, the outer membrane reaction of a new bone tumor realm more clearly. The original tumor cancellous bone most or all disappear, often fibrous tumor of bone or spacing. Because of the osteolytic tumor tissue damage, often causing pathologic fracture (Figure 17-5). Tumor tissue red, soft and crisp, larger tumor is often associated with hemorrhage and necrosis, and with cystic degeneration and the formation of the cavity size, intracavitary containing serous or bloody fluid. Advanced cases of osteoarthritis of the cladding, if damaged, can be a violation of soft tissue mass. Articular cartilage is the role of anti-tumor infiltration, articular cartilage bone stromal completely destroyed, resulting in the loss of articular cartilage and twisted support.