Thursday, March 6, 2008

Lupus nephritis which kidney performance?

Systemic lupus erythematosus is a clinical disease, which can occur at any age and sex, common in young women the most common for 20 - 30-year-old. Renal outside its performance : (a) general symptoms : Most patients performance malaise, weight loss, 90% of the patients have a fever, heat-volatile, 40% more than 39 ℃. (2) skin and mucosa : 50% of patients, there will be the butterfly facial erythema, lesions confined to the two cheek and nose, edema was mild erythema, it will be telangiectasia and scale, severe exudative inflammation may have blisters and crusts, Erythema general dissipated after leaving scars and pigmentation. Alopecia found in 50% of patients, SLE activity is a sensitive indicator. Livedo reticularis common vasculitis is a typical characteristic. Many neurological symptoms. In addition, we can see urticaria, discoid lupus, a week erythema, purpura, cleft Flake bleeding, oral and nasal ulcers. (3) joint and muscle : 90% of patients on the festival pain, commonly found in the limbs of small joints, About 10% of patients have mild joint deformities, but generally no signs of bone erosion. Long-term, large, irregular use of hormones, may lead to some patients developed aseptic necrosis of the femoral head.  1 / 3  patients of muscle-ache, and some of them have obvious symptoms of myasthenia gravis or muscle atrophy. (4) Cardiovascular : active SLE patients developed myopericarditis were up 2 / 3 of the cases, usually short, mild clinical manifestations. 10% of patients can myocarditis performance. Mitral and aortic valve can be involved, the general in the apex and the bottom of news and cardiac systolic murmur, which may also anemia, tachycardia, or fever, a rare diastolic murmur. In addition, there may also be Raynaud's phenomenon (about 25%), pulmonary hypertension and recurrent thrombotic phlebitis. The latter can be the first symptom of lupus erythematosus. (5), lungs and pleura : 40% ~ 46% of patients may occur pleurisy, It is about involving kidney lupus erythematosus credible indicators. Lupus acute pneumonia and rare performance of breathing difficulties, chest pain and cough without seriously, a lot can happen hemoptysis, some patients showed symptoms of atelectasis, few are as diffuse pulmonary fibrosis. (6) the blood system : 50% ~ 75% of patients are positive pigment cell anemia; 60% of patients leukocyte "4.5 × 109 / L; Platelet generally mild lower Minorities "30 × 109 / L (about 50%). (7) gastrointestinal tract : Some patients have nausea, vomiting, abdominal pain common (about 50%), peritonitis and may be related to the abdominal viscera. Liver, spleen were found in 30% and 20% of patients. (8) the nervous system : signs and symptoms of the incidence rate of about 50% ~ 60%, complex and diverse clinical manifestations. speaking mental disorder, such as depression, and other mental disorders. Also had epilepsy, migraine, hemiplegic, Huntington, peripheral neuropathy and diabetic retinopathy, etc.. (9) Other : menstrual irregularities, symptoms increase, particularly migraine. Some patients can have painless swelling of lymph nodes, swelling of the parotid gland, conjunctivitis. 

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