Marine anemia how to control?

Western sea for the treatment of anemia in general, therapeutic abortion, gene therapy, bone marrow transplantation and symptomatic treatment. One, prenatal diagnosis and gene therapy Marine anemia is a type autosomal genetic disorders. To combat these genetic diseases are two ways, one is given to the family of marine anemia correct genetic counseling, using a variety of molecular analysis of DNA genetic diagnosis methods for prenatal diagnosis and therapeutic abortions, guiding marine anemia family fertility, fundamentally control and eradication of marine anemia gene dissemination and proliferation. Another way is to find a pair of existing marine anemia patients effective treatment methods. The world has been on hemoglobin disease and anemia marine exploration gene therapy, such as the β marine anemia without mutation (this mutation is a point mutation, a nucleotide changes made from three nucleotide composition of the genetic signal into a termination signal, generated mRNA chain variable short) using artificial tRNA gene mutation induced transcription of it can identify tRNA termination password, can carry a specific amino acids, which can be placed on the original amino acid mutations caused by the wrong signal termination position and restore integrity of the β chain synthesis; it is reported with 5-azacytidine ( 5-azacytidine) in the treatment of anemia β marine obtained initial success. This is because not all have found the gene expression were methylated, and 5-azacytidine a demethylation and differentiation, can remove gamma-globin gene inhibition, and the synthesis of large gamma-globin chain to gamma-globin chain compensatory β chain and the lack of form of hemoglobin F, thereby correcting anemia. 2, allogeneic bone marrow transplantation Foreign countries have begun to allogeneic bone marrow transplantation in the treatment of the disease, with good results. Domestic marrow transplantation technology, equipment was ripe, can be used for the treatment of the disease. 3, the trial of 5-azacytidine, hydroxyurea therapy, such as beta-thalassemia and hemoglobin s disease can be so different degrees F with hemoglobin levels of hemoglobin. In addition, the experiment found that rhesus monkeys can busulfan the hemoglobin F synthesis. Therefore, the treatment of beta thalassemia, available daily oral busulfan per kg body weight of 0.15 to 0.25 mg, 20 consecutive days of a course of treatment. 50 days after treatment, hemoglobin started rising, Splenomegaly ease. While the WBC and platelet decline, but all in the normal range, without bone marrow suppression. Conditions have improved to varying degrees. 4, symptomatic treatment Symptomatic treatment is so symptomatic patients can be as close as possible to normal life, deferring blood disease, prevent infection. Right anemia light or asymptomatic heterozygotes β marine anemia, the condition of stable hemoglobin H disease and static, standards-α marine anemia, do not require treatment. ① transfusion To promote "high blood transfusion therapy," allowing patients to maintain a normal hemoglobin level can prevent tissue hypoxia caused by the series of pathological changes, such as bone changes, growth retardation, but the hemochromatosis bound to happen sooner or later. Long-term need for blood, preferably washed red blood cell transfusions in order to prevent irregularities of HLA transfusion reactions. ② iron chelator Application of iron chelating agent to accelerate the body's excretion of iron, so as to ease long-term massive transfusion of iron overload, postponed redness of the skin disease and reduce the incidence of redness of the skin disease symptoms. DFO - 0.5 to 1.0 grams, intramuscular injection once a day, early on 0.5 grams; Or 1.0 to 2.0 grams, intravenous infusion, intramuscular better efficacy. While medication for vitamin C150 ~ 250 mg of iron can increase excretion. But doses of vitamin C does not increase further increase the excretion of iron, vitamin C daily dose should not exceed 500 mg, in DFO-treated to a two-week vitamin C to avoid simultaneous use where impaired cardiac function. The drug side effects, occasionally allergies, pregnant women banned. ③ splenectomy Splenectomy is the oppression of abdominal viscera, handicapped persons; There hypersplenism, WBC, thrombocytopenia, viable splenectomy.