Multiple genetic bone cartilage tumor

[Outlined]
Multiple genetic bone cartilage tumor has three characteristics: ① ② with genetic deformities or bone shortening ③ dioxin into the peripheral chondrosarcoma of the high incidence of.
【 Clinical manifestations】
With single osteochondroma a ratio of 1:10. Owing to the multiple characteristics, the time of their symptoms than single osteochondroma morning, the 10-year-old former general. Symptoms light cases (especially in women) can be hidden life. Obviously occur in men, male to female ratio was 2:1.
By nearly 2 / 3 of cases has shown its hereditary. If the parents of a genetic bone cartilage with multiple tumors, their descendants will be in about half of a genetic disease, common in the male progeny. Breast cancer in the family, if a male member is normal, then he will not genetic disease to their offspring; on the contrary, in the same family, even if normal women can be the disease to their offspring. In other words, men, the sick and genetic capacity at the same time performance in women, diseases that can be hidden or not obvious, but it can be passed on to future generations.
Generally, with the symmetry of incidence, all of bone cartilage in the bone can become the osteochondroma location, the metaphyseal bone growth, the soft-bone of multiple and larger, especially neighboring knee, shoulder, hip, wrist the location and ankle, but it rarely occurred in the elbow and lighter. Multiple genetic bone in the trunk of bone cartilage also more common, occur in the second or sudden bone ossification centers nearby, in the scapula, mainly near spine edge of the bottom corner, acromion, joint glenoid and coracoid process; in the pelvic , mainly iliac crest in the spine, are mainly located in the spinous process and the transverse process in the ribs, more commonly found in bone or cartilage at the back-end connections. In addition to the second of the calcaneus bone, cartilage multiple genetic bone tumors occurred in carpal and not tarsal bones, as they epiphysis and the occurrence of bone same.
We can see and touch a symmetric multiple osteophytes biological, in more serious cases, with its characteristic performance alone can be made up of the diagnosis. In more serious cases, there may be the limb shortening, sometimes, very significant and dispersion, resulting in similar achondroplasia, however, of multiple genetic bone cartilage not achondroplasia characteristics, the growth cartilage function is normal. In fact, due to limb shortening is not caused by abnormal cartilage growth, but because of the proliferation potential of cartilage was external branch (osteochondroma) consumption, not for the bone caused by the extension. As a result of this external backbone of the Week scattered in diameter and composition of the upper limb, the two-leg on the uneven distribution of bone, it is often associated with abnormal limb shortening, for example, will have knee, ankle, elbow, wrist or inversion of valgus, the most typical deformities occurred in the forearm and chest. Because of the wrist in the event of the osteochondroma more than elbow, made of bone, 3 / 4 of bone lengthening occurred in the distal radius bone 4 / 5 of its bone lengthening occurred in the proximal, so always shorter than radial ulna bone malformations, or radial convex lateral and dorsal to the hand-foot-biased, sometimes dislocation of radial head.
【Prognosis:
Single cartilage and bone tumors, multiple genetic bone cartilage tumor growth at the end of the body also stop growing, such as individual cases of osteochondroma obvious growth in the adult is usually sarcoma signs of change, the rate of about 25% about. Multiple genetic bone sarcoma change cartilage tumors occurred in 15-year-old general after.