Mixed connective tissue disease renal damage which clinical

It may occur at any age, the average age of onset of about 30 ~ 40 years old, more common in women. The most common clinical manifestation : Polyarthritis, Renault levy that (toe) skin sclerosis, Myalgia and myositis associated with esophageal motility weakened. Face and hands of scleroderma-like performance Obviously, the joint involvement sometimes very serious, but not uncommon subcutaneous nodules, often a weak, marasmus. Damage was also common lung function may have varying degrees of pulmonary hypertension. Pericarditis and mitral valve prolapse is the most common cardiac involvement in the performance, interviews in 1 / 4 ~ 1 / 3 of patients. Blood system involvement found in half of patients with the most common anemia, leukopenia and thrombocytopenia occasionally. Found in the spleen increased 20% patients. Neuropsychiatric involvement nor rare, mainly aseptic meningitis-like syndrome of glucocorticoid response is good, Other performance nervousness, vertigo, convulsions and ataxia. CSF lymphocytes and protein increased. And systemic lupus erythematosus, a disease of the nervous system involvement is not the death. Kidney involvement in a variety of clinical manifestations, uneven, mostly for light, non-progressive. Can be in the form of asymptomatic proteinuria and / or hematuria, nephrotic syndrome or a different degree of renal dysfunction, However, it can be complete without clinical symptoms. Any of the following circumstances suggesting mixed connective tissue disease associated with renal damage : ① anti-ribosomal protein antibody levels; ② serum complement fall and / or anti-dsDNA antibody titer increased; ③ anti-nuclear antibodies. If a patient immunofluorescence anti-nuclear antibody negative basic kidney disease can be ruled out. Mixed connective tissue disease patients, kidney damage histological changes in the rate of much more than simple laboratory estimated incidence of kidney damage high.