Primary Sjögren's syndrome will damage the kidneys Why

Now that the disease is autoimmune diseases, and autoimmune reasons, is the inhibition of T cell activity and B cell activity increased. T-cell dysfunction of the peripheral evidence, including a decrease in the number of T lymphocytes and natural killer cell activity, Delayed hypersensitivity skin lacks, own mixed lymphocyte activity and the low concentration of phytohemagglutinin stimulation of the lack of response. B cell activity showed polyclonal agammaglobulinemia, monoclonal γ - globulin disease, multiple autoantibodies and circulating immune complexes exist. In addition to the main lesion violations lacrimal glands, salivary gland, and so on, also involving the lungs, kidneys, myocardium. For kidney disease to severe interstitial nephritis; Tubular atrophy, contour unclear. Irregular tubular basement membrane thickening and transparent tube formation; glomerular minor changes, were focal mesangial cell proliferation, mesangial matrix increase, the ball weeks fibrosis, occasionally glomerulosclerosis.