Thursday, March 6, 2008

Severe clinical manifestations of hepatitis?

Severe hepatitis is the basis of clinical manifestations of severe acute hepatitis and Asia of severe acute hepatitis. (1) severe acute hepatitis (fulminant hepatitis) : usually acute hepatitis onset of jaundice. illness within 10 days deteriorating rapidly, there ① jaundice rapidly deepening; ② obviously bleeding tendency; ③ atrophy of the liver, liver stink, Voiced liver sexual narrow sector; ④ nervous system symptoms of irritability, delirium, orientation, calculation of obstacles, lethargy and even coma. Most patients with cerebral edema; ⑤ hepatorenal syndrome, urinary, urine retention and azotemia. Laboratory examinations : serious damage to liver function, serum bilirubin in 171 μmol / L and above, prothrombin time was significantly longer, serum cholinesterase, cholesterol and cholesteryl ester lower, acute jaundice patients. as a result of high fever, severe gastrointestinal symptoms (such as extreme lack of appetite, frequent vomiting, abdominal distension or hiccup), extremely weak, Meanwhile behavioral abnormalities, personality change, disturbance of consciousness, coma abnormal spirit of prodromal symptoms, should consider this disease. Or jaundice that is very light, has not even appeared jaundice, but obviously abnormal liver function, but also has the digestive tract and the spirit of the above symptoms, should consider this disease. Often associated with upper gastrointestinal bleeding, cerebral edema, infection and acute renal failure and death. Course usually does not exceed 14 days. (2) subacute severe hepatitis : acute jaundice hepatitis, after the onset of over 10 days, within eight weeks. with the following indications : ① rapid rise jaundice (bilirubin up a few days more than 171 μmol / L), serious damage to liver function (ALT or elevated enzyme isolated bulbs, white / globulin inversion, gammaglobulin increase), prothrombin time was prolonged, or cholinesterase activity decreased significantly; ② height of weakness and loss of appetite, decrease intractable nausea and vomiting, severe abdominal distension and ascites, obviously bleeding tendency, irritable or lethargy. Liver can result in coma, and death hepatorenal syndrome, or the development of necrosis cirrhosis.

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