(1) For patients with liver diseases, Consideration should be given to possible drug-induced, it should be asked in detail about medication history, such as dosage, medication and began to stop time, the interval from the onset, such as. The literature data indicate that about 50% to 70% of the drug in patients with hepatitis medication within 2 weeks after onset, about 80% to 90% in the eight weeks of onset. In addition, should also understand what occupational contact with drugs or chemicals.
(2) whether the attention of fever, skin mucosal damage, skin rashes, joint pain and eosinophilia, and other allergic symptoms. We must pay attention to the size of the liver, because some drugs can cause asymptomatic hepatomegaly.
(3) should pay attention to the acute and chronic viral hepatitis, obstructive jaundice and cirrhosis, and other phase differential.
(4) liver biopsy examination, we can see that portal District inflammation, and a large number of eosinophil infiltration and cholestasis, conducive to drug-induced hepatitis diagnosis.
(5) Some people think that after the resumption of the liver, skin allergies do drugs test in the diagnosis of help. Some people recommend using a small dose of the drug challenge test, were measured before and after the administration of a variety of serum enzyme activity determination after administration has repeatedly significantly higher than before treatment, may consider drug-induced hepatitis. Drug provocation test but only 40% to 60% positive, and some duplication of administration a long time, provocation test there is still a risk, it can not be easily used.
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