Thursday, March 6, 2008
Pulmonary hemorrhage - nephritis syndrome TCM treatment?
Treatment is the key to early diagnosis and timely subject to effective treatment. (1) of adrenal cortical hormones and immune inhibitors : Taken in combination, can effectively curb the anti-basement membrane antibody formation, can quickly reduce the severity of pulmonary hemorrhage and control life-threatening hemoptysis. General availability of methylprednisolone pulse therapy, combined with immunosuppressants, such as cyclophosphamide or azathioprine; also a strong start to the relaxation and oral use of immunosuppressive agents such as cyclophosphamide or azathioprine. Disease control, immunization can be suspended inhibitors, prednisone slow to maintain the volume of 5 ~ 15 mg / d for further treatment. (2) plasma replacement therapy : plasma exchange treatment, joint use of immunosuppression and middle-dose corticosteroid therapy, to be effective in inhibiting pulmonary hemorrhage and improve renal function. For patients with rapidly progressive, if not yet occurred in oliguria, serum creatinine "530.4μmol / L before. it is better. Has entered the phase of terminal kidney disease, serum creatinine higher than 530.4 μmol / L need life-sustaining dialysis treatment, Efficacy was poor. Daily replacement plasma 2-4L, time and frequency can cycle-basement membrane antibody levels. Plus oral doses of prednisone (60 mg / d) and immunosuppressive drugs, 80% of patients improved renal function; I have impact on the treatment and difficult to control pulmonary hemorrhage, plasma exchange, have different levels of ease. (3) renal replacement therapy : conventional therapy or treatment late into end-stage renal disease, be hemodialysis or peritoneal dialysis to stay alive. If stable conditions, the blood circulation on the basement membrane antibody decreased renal transplantation can be considered. After renal transplantation can relapse, the precise incidence is hard to estimate, may relapse rate is not high. Some people think that pre - renal transplantation bilateral nephrectomy, but can reduce the recurrence of kidney transplantation there was insufficient evidence. (4) Other :-diagnosed patients with the disease, such as renal biopsy proven non-reversible damage, High-dose hormone therapy and plasmapheresis law difficult to control pulmonary hemorrhage may consider bilateral nephrectomy. Past that anticoagulant therapy right conditions improved to a certain extent, But recently some scholars that anticoagulant therapy increased the possibility of pulmonary bleeding and should not be used. Moreover, the strengthening of supportive therapy and infection control.
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