Sexual system sclerosis Why damage the kidneys?

Although the cause of scleroderma is still unclear, but more information confirmed that the disease and other connective tissue diseases, incidence with immune regulation disorder. Kidney disease damage occurred and vascular lesions are closely related : ① vasoconstriction in renal cortex, found in the majority of sexual System sclerosis with renal sclerosis patients, because of cold-induced Raynaud's phenomenon may increase the vasoconstriction; ② interlobar artery intimal proliferation and luminal stenosis, renal blood flow and stimulate the renin angiotensin system  enhanced vitality, Results from hypertension and vascular cortex further contraction, blood flow reduction, hypoxic cell swelling, focal necrosis in renal cortex, where renal failure. In addition intravascular coagulation and renal damage has occurred.